A COVID-19 vaccine is administered in Toronto on Monday, Dec. 14, 2020. THE CANADIAN PRESS/Frank Gunn

A COVID-19 vaccine is administered in Toronto on Monday, Dec. 14, 2020. THE CANADIAN PRESS/Frank Gunn

Clinical trials start for Canadian COVID-19 vaccine candidate

Dubbed COVAC-2, the vaccine hopeful was developed by the Vaccine and Infectious Disease Organization

Clinical trials have begun for another Canadian-made COVID-19 vaccine candidate, with three people receiving an initial dose on Wednesday.

The Canadian Center for Vaccinology says the first of 108 healthy adult volunteers received injections in Halifax. The placebo-controlled study will administer two doses to each volunteer, 28 days apart.

“It’s a product of Canadian science, so it bodes well for the ability to make vaccines here. We all want to have vaccine manufacturing capacity in Canada,” said Dr. Joanne Langley, a vaccine researcher with the centre.

She said that the pace of testing is careful, as different age groups, from younger to older, receive varying doses in a process that will unfold over the next two months.

Dubbed COVAC-2, the vaccine hopeful was developed by the Vaccine and Infectious Disease Organization, or VIDO, at the University of Saskatchewan in Saskatoon.

It’s the first of two subunit vaccines by VIDO to enter clinical testing. Subunit vaccines contain purified viral proteins that are not infectious, and employ technology already used in vaccines for hepatitis, diphtheria, and whooping cough.

Darryl Falzarano, a vaccine researcher at VIDO, said he’s hoping that his institute’s promising tests on ferrets and hamsters will translate into safe and effective results in the human testing phase.

“Safety is the primary indicator (in the first phase) but you will also be looking at immune response,” he said.

Langley said the testing in the first phase is to determine safety to humans, and the participants will keep a diary that measure any pain or redness of the arm. The trial will also measure antibody responses, she said.

The next step would be to do trials at multiple sites around the country.

It is only in Phase 3 that the vaccine is compared against a placebo or another vaccine to see how well it protects against COVID-19, said Langley.

She said the entire vaccine testing process, if all went well, could take about nine months, adding that is a “very wishful, optimistic scenario.”

VIDO has said in a news release the product doesn’t need ultra-cold storage temperatures like synthetic messenger RNA or mRNA products. The two Health Canada-approved vaccines by Moderna and Pfizer-BioNTech each require special distribution and storage procedures that have complicated their rollout.

It follows the launch last month of clinical trials for a prospective vaccine by Calgary’s Providence Therapeutics, and last year’s launch of trials for a vaccine hopeful by Quebec City’s Medicago.

VIDO’s vaccine antigen – a molecule that triggers an immune response – was produced at Quebec-based Biodextris using a cell line from the National Research Council of Canada.

Development help also came from partners around the world, including Seppic in France and the Vaccine Formulation Institute in Switzerland.

At the same time, VIDO is building a manufacturing facility on the USask campus that could produce up to 40 million vaccine doses, but it wasn’t certain if that would include VIDO’s product. Construction is expected to be completed late this year.

Falzarano said the team in Saskatoon is excited the process is beginning, as this form of vaccine can be mass produced at a rapid rate if successful.

“It’s only the beginning of a multi-step process, but at least we’ve gotten to this milestone,” he said.

ALSO READ: Experts say race for COVID drugs dogged by false promises, lack of co-ordination

Michael Tutton and Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Just Posted

Patrons rip around a corner on the go-kart course at Lakeshore Go-Karts and Mini-Golf. (Photo by Megan Roth/Sylvan Lake News)
Sylvan Lake go-kart and mini golf course reopens after fire

Last August the outdoor facility was shut down after a fire burned through much of the business

(File photo from The Canadian Press)
Red Deer down to 66 active COVID-19 cases

Red Deer has lowest number of active cases since last November

A small selection of shoes line a step at the Municipal Government Building in Sylvan Lake, with each pair representing a vicitm of residential schools in Canada. Tracey Greinke placed the first pair of shoes on the steps, hoping more would follow. (Photo by Megan Roth/Sylvan Lake News)
Sylvan Lake woman sets up small memorial for residential school victims

Tracey Grienke placed a pair of moccasins on the steps of town hall, and a few more followed

FILE – Perry Bellegarde, National Chief of the Assembly of First Nations, takes part in an event on Parliament Hill in Ottawa on Tuesday, July 7, 2020. THE CANADIAN PRESS/Sean Kilpatrick
Indigenous Peoples Day must be a ‘call to action’, says Assembly of First Nations chief

Discovery of children at Kamloops residential school site must lead to change, Perry Bellegarde says

Left handed pitcher Evan Wilde started the game for Sylvan Lake and allowed four runs in the 12-10 extra-innings loss against the Edmonton Prospects on Sunday in Western Canadian Baseball League play. (Photos by Byron Hacket/Blakc Press News Media)
Historic opening weekend for Sylvan Lake Gulls

The Gulls finished the opening weekend with one win and two losses

The border crossing into the United States is seen during the COVID-19 pandemic in Lacolle, Que. on February 12, 2021. THE CANADIAN PRESS/Paul Chiasson
VIDEO: Border quarantine to soon lift for fully vaccinated Canadians

Eligible travellers must still take multiple COVID-19 tests

Fans watch the warm-up before Game 6 between the Toronto Maple Leafs and the Montreal Canadiens in NHL playoff hockey action Saturday, May 29, 2021 in Montreal. Quebec’s easing of COVID-19 restrictions will allow 2,500 fans to attend the game for the first time in fourteen months. THE CANADIAN PRESS/Ryan Remiorz
Two-thirds of Canadians say governments shouldn’t lift all COVID-19 restrictions

Poll reports Canadians who gained pandemic weight say they have gained 16 pounds on average

Paul Bernardo is shown in this courtroom sketch during Ontario court proceedings via video link in Napanee, Ont., on October 5, 2018. Teen killer and serial rapist Paul Bernardo is set for a parole hearing today. The designated dangerous offender, has been eligible for full parole for more than three years. Bernardo’s horrific crimes in the 1980s and early 1990s include for kidnapping, torturing and killing Kristen French and Leslie Mahaffy near St. Catharines, Ont. THE CANADIAN PRESS/Greg Banning
Killer rapist Paul Bernardo faces parole hearing today; victim families opposed

Designated dangerous offender has been eligible for full parole for more than three years.

People look over the damage after a tornado touched down in Mascouche, Que., north of Montreal, Monday, June 21, 2021. Dozens of homes were damaged and one death has been confirmed. THE CANADIAN PRESS/Ryan Remiorz
One dead and extensive damage as tornado hits Mascouche, Que., north of Montreal

Damage reported in several parts of the city, and emergency teams dispatched to sectors hardest hit

FILE - In this Nov. 29, 2020, file photo, Las Vegas Raiders defensive end Carl Nassib leaves the field after an NFL football game against the Atlanta Falcons in Atlanta. Nassib on Monday, June 21, 2021, became the first active NFL player to come out as gay. Nassib announced the news on Instagram, saying he was not doing it for the attention but because “I just think that representation and visibility are so important.” (AP Photo/John Bazemore, File)
Nassib becomes first active NFL player to come out as gay

More than a dozen NFL players have come out as gay after their careers were over

A pair of Alberta residents were arrested after police responded to a report of a woman who had allegedly been assaulted and confined against her will on June 20, 2021. (File photo)
Salmon Arm RCMP arrest 2 Albertans suspected in alleged assault, unlawful confinement

Firearms, stolen items seized including NHL hockey cards believed to be worth thousands

A man makes his way past signage to a mass COVID-19 vaccination centre at the University of Toronto’s Mississauga campus during the COVID-19 pandemic in Mississauga, Ont., on Monday, May 17, 2021. THE CANADIAN PRESS/Nathan Denette
Canadians encouraged to see mRNA shots as interchangeable as more 2nd doses open up

Doctors urge people not to hesitate if offered Moderna after getting Pfizer for their first shot

Chief of Defence Staff Jonathan Vance sits in the front row during a news conference in Ottawa on June 26, 2020. THE CANADIAN PRESS/Adrian Wyld
Defence committee rises without report on Vance allegations

Committee had been investigating the government’s handling of complaints against former defence chief

Tl’etinqox-lead ceremony at the site of the former St. Joseph’s Mission in Williams Lake, B.C., June 18, 2021. (Angie Mindus photo - Williams Lake Tribune)
‘We are all one people’: Honouring residential school victims and survivors

Love, support and curiousity: Canadians urged to learn about residential schools and their impact

Most Read